PRODUCT DETAILS
About CLACIL-625 Tablet , 10's
Amoxycillin 500 mg + Clauvulanic acid 125 mg + Lactobacillus 60 million spores

CLACIL-625 Tablet belongs to a group of antibiotics known as penicillin combination. It is a broad- spectrum antibiotic that works against various types of bacteria. CLACIL-625    Tablet is made up of two medicines: Amoxicillin (the active part of antibiotic) & Clavulanic acid (that boosts the efficacy of the amoxicillin). CLACIL-625    Tablet is generally prescribed to prevent middle ear and sinus infections, throat or lung respiratory tract infections, urinary tract infections, skin infections, soft tissue infections, dental infections, joint and bone infections.

Infectious or harmful bacteria can make you sick and reproduce quickly in your body. These harmful bacteria produce chemicals known as toxins, which can damage tissue and make you sick. Amoxicillin acts by destroying the outer protein layer, thereby killing the bacteria (bactericidal). Clavulanic acid inhibits the enzyme beta-lactamase that prevents bacteria from destroying the efficacy of amoxicillin. As a result, the action of Clavulanic acid allows Amoxicillin to work better and kill the bacteria. 

CLACIL-625   Tablet does not work against infections caused by viruses, including cold and flu. MOXYCLACIL-625  Tablet should be taken as prescribed by your doctor, preferably with a meal to avoid stomach upset and at fixed intervals every day for best results.The dose of CLACIL-625  Tablet can vary depending upon your condition and  the severity of the infection. Also, it is recommended to complete the course of medicine even if you feel better as it is an antibiotic, and leaving it in between may lead to even severe infection that will, in fact, stop responding to the antibiotic as well (antibiotic resistance). The common side effects of CLACIL-625  Tablet include vomiting, nausea, and diarrhea. Everyone need not experience the above side effects. In case of any discomfort, speak with a doctor. Before starting  CLACIL-625    Tablet please inform your doctor if you have any allergy (against any antibiotic), kidney or liver problems. Do not take  CLACIL-625   Tablet on your own as self-medication may lead to antibiotic resistance in which antibiotics fail to act against specific bacterial infections. Uses of CLACIL-625   Tablet

Bacterial Infections (Ear infections (acute otitis media), Bronchitis, Pneumonia, Urinary tract infections, skin infections, etc.)

Medicinal Benefits CLACIL-625Tablet is a broad-spectrum antibiotic that covers a very wide range of bacterial infections.CLACIL-625Tablet has the advantage of having Clavulanic acid, which protects amoxicillin from getting destroyed by the bacterial enzyme increasing its efficacy. Besides this, it helps overcome antibiotic resistance in bacteria caused by the enzyme which destroys amoxicillin (beta-lactamase). This makes the drug effective in multiple infections like ear infections (acute otitis media), bronchitis, pneumonia, urinary tract infections, skin infections, etc. It can be used safely in children, pregnancy, and breastfeeding if taken at the prescription of the doctor.

Directions for Use
Swallow the tablet whole with a glass of water at the start of a meal or slightly before. Space the doses evenly during the day, as prescribed by your doctor. Do not chew or crush it. If you cannot swallow the tablet as a whole, you may break the pill into half and take both halves one at a time.

Storage
Store in a cool and dry place away from sunlight

Side Effects of CLACIL-625   Tablet
Most of the side effects of  CLACIL-625 Tablet  do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor. Some common side effects of CLACIL-625  Tablet are vomiting, diarrhea, indigestion, etc. Some people may be allergic to the penicillin group of antibiotics. So a 'sensitivity test' may be required before use. Inform your doctor if you are allergic to any antibiotic or the penicillin group of antibiotics in particular. Everyone doesn't need to experience the above side effects. In case of any discomfort, speak with your doctor.

In-Depth Precautions and Warning Drug Warnings

After taking  CLACIL-625Tablet  if you have an allergy-like symptom, including rash, swelling of the face/lips/throat, difficulty in breathing, or tightness in the chest, immediately contact your doctor. Do not take CLACIL-625 Tablet if you have an allergy to CLACIL-625  Tablet  penicillin or cephalosporin class of antibiotics as it may cause skin rash, itching, and difficulty in breathing. People having a liver disease or jaundice (yellowing of skin/eye) should not take CLACIL-625  Tablet  as it can damage your liver severely. You may have diarrhea in some cases, which can be managed by taking it with any probiotics and plenty of fluids. 
Drug Interactions
Drug-Drug Interaction: Care should be exercised when CLACIL-625 Tablet is administered in combination with gout medicine (allopurinol, probenecid), blood thinner (warfarin), anticancer, or anti-arthritis drug (methotrexate), and drug to prevent organ transplant (mycophenolate mofetil).
Drug-Food Interaction: Avoid eating high-fat meals as this makes it harder for your body to absorb  CLACIL-625 Tablet
Drug-Disease Interaction:  People affected with liver disease (like jaundice), glandular fever (viral infection with fever and sore throat), colitis (bowel disease that affects the large intestine, causing irritation, inflammation, and ulcers in the colon) should not take CLACIL-625 Tablet


Safety Advice

* ALCOHOL
It is advisable to avoid the consumption of alcohol during the treatment with  CLACIL-625 Tablet, as it may worsen the side effects like dizziness and fits.
* PREGNANCY
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
* BREASTFEEDING
This medication passes into breast milk. Consult your doctor before breast-feeding.
* DRIVING
CLACIL-625  Tablet may cause dizziness in some people, so it may affect your ability to drive.
*LIVER
CLACIL-625  Tablet  to be taken with caution, especially if you have a history of liver diseases/conditions. Dose may have to be adjusted by your doctor.
* KIDNEY
CLACIL-625 Tablet to be taken with caution, especially if you have a history of kidney diseases/conditions. Dose may have to be adjusted by your doctor.
*Habit Forming
No

Diet & Lifestyle Advise

Probiotics should be taken after taking a full course of  CLACIL-625 Tablet 10's in order to restore some healthy bacteria in the intestines that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yogurt, cheese, sauerkraut, kombucha, & kimchi can help restore the intestine's good bacteria.Include more fibre enriched food in your diet, as it can be easily digested by your gut bacteria, which helps stimulate their growth. Thus, fibre rich foods may help restore healthy gut bacteria after a course of antibiotics. Whole grains like whole-grain bread, brown rice should be included in your diet.
Avoid alcoholic beverages with CLACIL-625  Tablet 10's as it can make you dehydrated and may affect your sleep. This can make it harder for your body to aid the  CLACIL-625   Tablet 10's in fighting off infections.
Special Advise
CLACIL-625 Tablet 10's is preferably taken with meals as it can lead to stomach upset. Drink itwith a full glass of water.To prevent throat irritation, take  CLACIL-625 Tablet 10's in an uprightposition. Do not lie down for at least 30 minutes of taking it. Even if you feel better after taking  CLACIL-625 Tablet 10's, do not stop taking it until your doctor says so. This might cause the symptoms to reappear and make the infection difficult to treat due to antibiotic resistance. Make sure you drink plenty of fluids when you are sick. This will, in general, help you clear out the infection faster, protect you from dehydration, and help you overcome some unpleasant side effects of taking CLACIL-625 Tablet 10's.
Some people may be allergic to  CLACIL-625 Tablet 10's or other penicillin or cephalosporin group of antibiotics. So a prior sensitivity test may be necessary. Inform your doctor if you are allergic to any medicine, particularly antibiotics belong to these groups.

If you feel nauseous after taking CLACIL-625 Tablet 10's, stick to simple meals like porridge, khichdi, dal roti, and other home-cooked meals. Avoid spicy and fatty food.

Spectrum
Gram +ve/ Aerobes
Strepto, Staphylo
Gram-ve/Aerobes
Neisseria, Klebsiella,Haemophilus,E. coli,Moraxella, Proteus
Anaerobes
Bacteroides,Peptostreptococcus

Mode of action
Amoxycillin inhibits bacterial cell wall synthesis Clavulanic acid binds and inhibits betalactamase enzymes that inactivate Amoxycillin

Pharmacokinetics
Pharmacokinetic s of Amoxycillin are not affected by Clavulanic acid

Amoxy
Cmax-7.2 mcg/ml,
Plasma protein binding-17-20%,
Half life – 1.4 hrs, 80% of drug excreted in Urine,
MIC -2mcg/ml

Clav
Cmax-2.4 mcg/ml,
Plasma protein binding-22-30%,
Half life – 1.2 hrs, 50% of drug excreted in Urine,
MIC-2 mcg/ml

Indications:
LRTI,URTI, Uncomplicated UTI,SSTI, Infection in Otitis media
Dosage:
2-3 times daily
Contraindications:

Hypersensitive to any ingredient
Side effects
Well tolerated. Diarrhea, Nausea, Vomiting, Skin rashes

Drug Interaction
Amoxy- Clav may reduce the efficacy of oral contraceptive by altering the gut flora to result in lower estrogen re-absorption